Adherence to treatment as a prognostic factor for histoplasmosis in a patient with AIDS
DOI:
https://doi.org/10.5935/2764-734X.e20230617Keywords:
Histoplasmosis, Acquired immunodeficiency syndrome, Cooperation and adherence to treatment, Case ReportAbstract
The clinical management of histoplasmosis is dependent on the recognition of risk factors, their early diagnosis, and adequate adherence to treatment. Although histoplasmosis is a potentially serious disease, it is curable. The aim of this study was to report a case of histoplasmosis in a patient with AIDS, which progressed with unfavorable clinical repercussions due to poor adherence to treatment and lack of effective outpatient follow-up after several hospitalizations.
References
1. Fortaleza SCB, Lopes SKA, Bandeira TJ, Nogueira TNAG, Holanda MA. Histoplasmose disseminada aguda em indivíduo imunocompetente. J Bras Pneumol. 2004;30(3):270-3.
2. Almeida MA, Almeida-Silva F, Guimarães AJ, Almeida-Paes R, Zancopé-Oliveira RM. The occurrence of histoplasmosis in Brazil: a systematic review. Int J Infect Dis. 2019;86:147-56.
3. Simms A, Kobayashi T, Endelman L, Sekar P. Disseminated histoplasmosis presenting as bilateral lower extremity paresis. Int J Infect Dis. 2020;95:265-7.
4. Marsilla MM, Khairunisa AA, Azyani Y, Petrick P. Disseminated histoplasmosis mimicking an acute appendicitis. Malays J Pathol. 2019;41(2):223-7.
5. Shahani L. Disseminated histoplasmosis mimicking relapsed chronic lymphocytic leukaemia. BMJ Case Rep. 2018; 2018:1-4.
6. Ferguson-Paul K, Park C, Childress S, Arnold S, Ault B, Bagga B. Disseminated histoplasmosis in pediatric kidney transplant recipients — a report of six cases and review of the literature. Pediatr Transplant. 2018;22(7):e13274. DOI: https://onlinelibrary.wiley.com/doi/full/10.1111/petr.13274
7. Azar MM, Loyd JL, Relich RF, Wheat LJ, Hage CA. Current concepts in the epidemiology, diagnosis, and management of histoplasmosis syndromes. Semin Respir Crit Care Med. 2020;41(1):13-30.
8. Mittal J, Ponce MG, Gendlina I, Nosanchuk JD. Histoplasma capsulatum: mechanisms for pathogenesis. Curr Top Microbiol Immunol. 2019;422:157-91.
9. Azar MM, Hage CA. Clinical perspectives in the diagnosis and management of histoplasmosis. Clin Chest Med. 2017;38(3):403-15.
10. Wheat LJ, Azar MM, Bahr NC, Spec A, Relich RF, Hage C. Histoplasmosis. Infect Dis Clin North Am. 2016;30(1):207-27.
11. Kauffman CA. Histoplasmosis: a clinical and laboratory update. Clin Microbiol Rev. 2007;20(1):115-32.
12. Falci DR, Monteiro AA, Caurio CFB, Magalhães TCO, Xavier MO, Basso RP, et al. Histoplasmosis, an underdiagnosed disease affecting people living with HIV/AIDS in Brazil: results of a multicenter prospective cohort study using both classical mycology tests and histoplasma urine antigen detection. Open Forum Infectious Diseases [Internet]. 2019;6(4):ofz073. Available from: https://academic.oup.com/ofid/article/6/4/ofz073/5319214
13. Wheat LJ, Freifeld AG, Kleiman MB, Baddley JW, McKinsey DS, Loyd JE, et al. Infectious Diseases Society of America. Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Diseases Society of America. Clin Infect Dis. 2007;45(7):807-25.
14. Wheat J, Hafner R, Korzun AH, Limjoco MT, Spencer P, Larsen RA, et al. Itraconazole treatment of disseminated histoplasmosis in patients with the acquired immunodeficiency syndrome. AIDS Clinical Trial Group. Am J Med. 1995;98(4):336-42.
15. Dismukes WE, Bradsher Junior RW, Cloud GC, Kauffman CA, Chapman SW, George RB, et al. Itraconazole therapy for blastomycosis and histoplasmosis. NIAID Mycoses Study Group. Am J Med. 1992;93(5):489-97.
16. Ferreira MS, Borges AS. Histoplasmose. Rev Soc Brasil Med Trop. 2009;42(2):192-8.
17. Wheat LJ, Connolly P, Smedema M, Brizendine E, Hafner R; AIDS Clinical Trials Group and the Mycoses Study Group of the National Institute of Allergy and Infectious Diseases. Emergence of resistance to fluconazole as a cause of failure during treatment of histoplasmosis in patients with acquired immunodeficiency disease syndrome. Clin Infect Dis. 2001;33(11):1910-3.
18. Wheat J. Histoplasmosis. Experience during outbreaks in Indianapolis and review of the literature. Medicine (Baltimore). 1997;76(5):339-54.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Infections in Evidence

This work is licensed under a Creative Commons Attribution 4.0 International License.
The Copyright Transfer Agreement also understands that the authors guarantee that the respective Case Report has never been published in another communication vehicle or scientific journal. Papers presented at meetings and/or scientific congresses may be published in the electronic journal INFECTIOUS DISEASES IN EVIDENCE - Case Reports, provided that they have not been published in whole or in part in their Proceedings or Annals.