Mycobacterium mucogenicum related to granulomatosis with polyangiitis: infection or colonization?

Authors

  • Mariana Lanna Magalhães Instituto de Infectologia Emilio Ribas - São Paulo - SP - Brasil
  • José Angelo Lauletta Lindoso Faculdade de Medicina da Universidade de São Paulo, Instituto de Medicina Tropical - São Paulo - SP - Brasil

DOI:

https://doi.org/10.5935/2764-734X.e20231233

Keywords:

Non-tuberculous mycobacteria, Granulomatosis with polyangiitis, Vasculitis, Molecular Biology, Case Report

Abstract

Advances in diagnostic methods, especially molecular biology, have made the identification of microorganisms easier and more sensitive. However, this progress also requires a better assessment of the clinical significance of the isolated microorganism, since in many situations this agent may only be contaminant or tissue colonization. Non-tuberculous mycobacteria are good examples of this duality and can cause both a range of clinical infections or only colonize certain sites in the body. In this report, we describe the case of a previously healthy patient with ulcerated lesions of the skin and mucous membranes with a chronic and progressive evolution. After various tests and evaluations, granulomatosis with polyangiitis was diagnosed. However, the biopsy of the nasolabial lesion also identified the presence of Mycobacterium mucogenicum using molecular biology. This identification raised many doubts in the medical teams about the real role of this Non-tuberculous mycobacteria in the pathogenesis or aggravation of the lesions, with decision-making implications about its specific treatment (or not), since the patient would be undergoing immunosuppressive therapy.

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Published

2024-02-27

How to Cite

Magalhães, M. L., & Lindoso, J. A. L. (2024). Mycobacterium mucogenicum related to granulomatosis with polyangiitis: infection or colonization?. Infections in Evidence, 2, e20231233. https://doi.org/10.5935/2764-734X.e20231233

Issue

Vol. 2 (2023)

Section

Case Reports

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