Challenges in the diagnosis and management of neuroparacoccidioidomycosis associated with pulmonary tuberculosis

Authors

  • Yago Caetano de Sousa Almeida Instituto de Infectologia Emílio Ribas - São Paulo - SP- Brasil.
  • Zarifa Khoury Instituto de Infectologia Emílio Ribas, Micoses sistêmicas - São Paulo - SP - Brasil.
  • Natália Totti Martins Instituto de Infectologia Emílio Ribas - São Paulo - SP- Brasil.
  • Renata Bacic Palhares Instituto de Infectologia Emílio Ribas, Patologia - São Paulo - SP - Brasil.
  • Evelyn Lepka de Lima Instituto de Infectologia Emílio Ribas - São Paulo - SP- Brasil.
  • Abimael Coutinho da Silva Instituto de Infectologia Emílio Ribas - São Paulo - SP- Brasil.

DOI:

https://doi.org/10.5935/2764-734X.e20240135

Keywords:

Invasive Fungal Infections, Central Nervous System Fungal Infections, Paracoccidioidomycosis, Case Report

Abstract

Paracoccidioidomycosis is one of the most relevant systemic mycoses in Latin America, especially in Brazil where it has the highest prevalence. Central nervous system involvement is a serious complication of the disease and requires early identification and treatment to achieve an effective clinical cure. Current treatments are prolonged, with considerable toxicity and, adding to the severity of the cases, result in high morbidity rates. The present report refers to a patient with no known previous immunodepression who presented with central nervous system infection by the fungus Paracoccidioides spp,. associated with pulmonary only tuberculosis. Although initially misdiagnosed, the disease was confirmed by pathology and the initial treatment consisted of a loading dose of liposomal amphotericin B, followed by consolidation with high-dose fluconazole. The patient had a good clinical course.

References

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Published

2024-03-06

How to Cite

Almeida, Y. C. de S., Khoury, Z., Martins, N. T., Palhares, R. B., Lima, E. L. de, & Silva, A. C. da. (2024). Challenges in the diagnosis and management of neuroparacoccidioidomycosis associated with pulmonary tuberculosis. Infections in Evidence, 3, e20240135. https://doi.org/10.5935/2764-734X.e20240135

Issue

Vol. 3 (2024)

Section

Case Reports

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