Purpura fulminans on invasive meningococcal disease
DOI:
https://doi.org/10.5935/2764-734X.e202201006Keywords:
Meningococcal Infections, Neisseria meningitidis, Serogroup W-135, Purpura FulminansAbstract
Meningococcal disease has been responsible for millions of deaths in its epidemics worldwide. This report aims to highlight the rapid evolution of this currently less prevalent disease and its main complication, purpura fulminans, a rare and highly lethal syndrome, as well as to comment on its clinical and surgical management. This is a 23-year-old female healthcare professional who was diagnosed with meningoccemia caused by serogroup-W N. meningitidis, clinically progressing with purpura fulminans and subsequent need for amputation of the affected segments, in addition to other complications. The patient was not vaccinated for this serogroup, which would have avoided this serious condition - vaccination should be considered for the risk group to which she belonged. It’s an important case report in order to not forget diseases that are allegedly under control, but decades or centuries ago generated major health problems.
References
1. Focaccia R. Doença meningocócica. In: Veronesi R, Focaccia R, eds. Tratado de infectologia. 5ª ed. São Paulo: Atheneu; 2015. p. 1053-66.
2. Ministério da Saúde (BR). Secretaria de Vigilância em Saúde. Situação epidemiológica da doença meningocócica, Brasil, 2007-2013. Boletim epidemiológico - volume 47, nº 29, 2016 [Internet]. Brasília (DF): Ministério da Saúde; 2020; [acesso em 2020 Dez 20]. Disponível em: https://www.gov.br/saude/pt-br/assuntos/boletins-epidemiologicos/numeros-anteriores
3. Ministério da Saúde (BR). Meningite [Internet]. Brasília (DF): Ministério da Saúde; 2020; [acesso em 2020 Dez 20]. Disponível em: https://www.gov.br/saude/pt-br/assuntos/saude-de-a-a-z/m/meningite
4. Guiddir T, Gros M, Hong E, Terrade A, Denizon M, Deghmane AE, et al. Unusual initial abdominal presentations of invasive meningococcal disease. Clin Infect Dis. 2018 Oct;67(8):1220-7. DOI: https://doi.org/10.1093/cid/ciy257
5. Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Crit Care Med. 2021 Nov;49(11):e1063-e43. DOI: https://doi.org/10.1097/CCM.0000000000005337
6. Abe R, Oda S, Sadahiro T, Nakamura M, Hirayama Y, Tateishi Y, et al. Gram-negative bacteremia induces greater magnitude of inflammatory response than Gram-positive bacteremia. Crit Care. 2010 Mar;14(2):R27. DOI: https://doi.org/10.1186/cc8898
7. Chalmers E, Cooper P, Forman K, Grimley C, Khair K, Minford A, et al. Purpura fulminans: recognition, diagnosis and management. Arch Dis Child. 2011;96(11):1066-71. DOI: https://doi.org/10.1136/adc.2010.199919
8. Colling ME, Bendapudi PK. Purpura fulminans: mechanism and management of dysregulated hemostasis. Transfus Med Rev. 2018 Apr;32(2):69-76. DOI: https://doi.org/10.1016/j.tmrv.2017.10.001
9. Ministério da Saúde (BR). Secretaria de Vigilância em Saúde. Departamento de Imunização e Doenças Transmissíveis. Coordenação-Geral do Programa Nacional de Imunizações. Manual dos centros de referência para imunobiológicos especiais [Internet]. 5ª ed. Brasília (DF): Ministério da Saúde; 2019; [acesso em 2020 Dez 20]. Disponível em: https://pesquisa.bvsalud.org/bvsms/resource/pt/mis-40552
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