Infectious endocarditis caused by Haemophilus parainfluenza
DOI:
https://doi.org/10.5935/2764-734X.e20240236Keywords:
Endocarditis, Bacterial, Haemophilus Infections, Haemophilus parainfluenzae, Case ReportsAbstract
Infective endocarditis caused by bacteria from the HACEK group - Haemophilus spp. (excluding Haemophilus influenza), Aggregatibacter actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens and Kingella kingae - is rare; affected patients are usually young and present with predisposing factors, such as heart disease. The infection is characterized by an insidious clinical course of subacute presentation, with an average delay in diagnosis of one to three months, which may be related to the formation of larger valve vegetations and a consequent increased risk of embolization. This report describes a case of a young, previously healthy girl whose primary clinical complaint was headache and fever. The diagnostic suspicion arose after Haemophilus parainfluenza positive blood culture and was confirmed by the echocardiographic visualization of a vegetation adhering to the posterior leaflet of the mitral valve. There was a good clinical response to treatment with ceftriaxone for six weeks; however, after three months, surgery for valve replacement was necessary.
References
1932-5
2. Chambers ST, Murdoch D, Morris A, Holland D, Pappas P, Almela M, et al. HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort. PLoS One. 2013;8(5):e63181. DOI: 10.1371/journal.pone.0063181
3. Ferro JM, Fonseca AC. Infective endocarditis. Handb Clin Neurol. 2014;119:75-91. DOI: 10.1016/B978-0-7020-4086-3.00007-2
4. Delgado V, Marsan NA, Waha S, Bonaros N, Brida M, Burri H, et al. 2023 ESC Guidelines for the management of endocarditis. Eur Heart J. 2023;44(39):3948-4042. DOI: 10.1093/eurheartj/ehad193
5. Holland TL, Baddour LM, Bayer AS, Hoen B, Miro JM, Fowler Junior VG. Infective endocarditis. Nat Rev Dis Primers. 2016;2:16059. DOI: 10.1038/nrdp.2016.59
6. Fowler VG, Durack DT, Selton-Suty C, Athan E, Bayer AS, Chamis AL, et al. The 2023 Duke-International Society for Cardiovascular Infectious Diseases Criteria for Infective Endocarditis: Updating the Modified Duke Criteria. Clin Infect Dis. 2023;77(4):518-26. DOI: 10.1093/cid/ciad271
7. Yew HS, Chambers ST, Roberts SA, Holland DJ, Julian KA, Raymond NJ, et al. Association between HACEK bacteraemia and endocarditis. J Med Microbiol. 2014;63(Pt 6):892-5. DOI: 10.1099/jmm.0.070060-0
8. Gagliardi R, Sensi C, Flaminio G, De Canale E, Vettor R, De Carlo E. Haemophilus parainfluenzae endocarditis in a low-risk woman: a case report. Clin Case Rep. 2021;9(11):e05066. DOI: 10.1002/ccr3.5066
9. Baddour LM, Wilson WR, Bayer AS, Fowler Junior VG, Tleyjeh IM, Rybak MJ, et al. Infective endocarditis in adults: diagnosis, antimicrobial therapy, and management of complications: a scientific statement for healthcare professionals from the American Heart Association. Circulation 2015;132:1435-86. DOI: 10.1161/CIR.0000000000000296
10. Mohananey D, Mohadjer A, Pettersson G, Navia J, Gordon S, Shrestha N, et al. Association of vegetation size with embolic risk in patients with infective endocarditis: a systematic review and meta-analysis. JAMA Intern Med. 2018;178(4):502-10. DOI: 10.1001/jamainternmed.2017.8653
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Infections in Evidence

This work is licensed under a Creative Commons Attribution 4.0 International License.
The Copyright Transfer Agreement also understands that the authors guarantee that the respective Case Report has never been published in another communication vehicle or scientific journal. Papers presented at meetings and/or scientific congresses may be published in the electronic journal INFECTIOUS DISEASES IN EVIDENCE - Case Reports, provided that they have not been published in whole or in part in their Proceedings or Annals.