Nosocomial infection by Cupriavidus metallidurans

Authors

  • Fernando José Chapermann Prefeitura da Cidade do Rio de Janeiro - Hospital Municipal Miguel Couto, Clínica Médica - Rio de Janeiro - RJ - Brasil.
  • Ricardo Sartorato Programa de Engenharia Biomédica/ COPPE-UFRJ, Processamento de Sinais Biológicos - Rio de Janeiro - RJ - Brasil.

DOI:

https://doi.org/10.5935/2764-734X.e20240945

Keywords:

Ralstonia, Cupriavidus, Mass Spectrometry Matrix-Assisted Laser Desorption-Ionization, Health Care Associated Infection, Case Report.

Abstract

A 68-year-old male patient remained in the intensive care unit for 75 days after surgery for drainage of intraparenchymal cranial hemorrhage and placement of an external ventricular drain. During his prolonged hospitalization, his prognosis was complex, with several complications and infectious episodes from various sources. During this period, Cupriavidus metallidurans (identified via the MALDI-TOF MS technique) was detected in two peripheral blood culture samples collected 26 days apart. In addition to the particularities of this bacterium, which is rarely isolated in the hospital environment, the review of this case led us to consider this agent as capable of causing active infection, which could have been a possible cause of the patient’s death.

References

1. D'Inzeo T, Santangelo R, Fiori B, De Angelis G, Conte V, Giaquinto A, et al. Catheter-related bacteremia by Cupriavidus metallidurans. Diagn Microbiol Infect Dis. 2015 Jan;81(1):9-12. DOI: 10.1016/j.diagmicrobio.2014.09.015

2. Procop G, Church D, Hall G, Janda W, Koneman E, Schreckenberger P. The Nonfermentative Gram-negative Bacilli. In: Koneman's Color Atlas and Textbook of Diagnostic Microbiology. 7th ed. Philadelphia: Wolters Kluwer Health; 2017. p. 797-1059.

3. Notaro A, Vanacore A, Molinaro A, Speciale I. Structure and Conformation Study of the O-Antigen from the Lipopolysaccharide of Cupriavidus metal lidurans CH34. Polysaccharides. 2022; 3(1):188-99. DOI: 10.3390/polysaccharides3010009

4. Falkinham III JO. Introduction to Emerging Opportunistic Premise Plumbing Pathogens. In: Opportunistic Premise Plumbing Pathogens. Singapura: Jenny Stanford Publishing Pte Ltd; 2023. DOI: 10.1201/9781003321002

5. Monsieurs P, Provoost A, Mijnendonckx K, Leys N, Gaudreau C, Van Houdt R. Genome Sequence of Cupriavidus metallidurans Strain H1130, Isolated from an Invasive Human Infection. Genome Announc. 2013;1(6):e01051-13. DOI: 10.1128/genomeA.01051-13

6. Diels L, Van Roy S, Taghavi S, Van Houdt R. From industrial sites to environmental applications with Cupriavidus metallidurans. 2009;96(2):247-58. DOI: 10.1007/s10482-009-9361-4

7. Wauters G, Claeys G, Verschraegen G, De Baere T, Vandecruys E, Van Simaey L, et al. Case of catheter sepsis with Ralstonia gilardii in a child with acute lymphoblastic leukemia. J Clin Microbiol. 2001;39(12):4583-4. DOI: 10.1128/JCM.39.12.4583-4584.2001

8. Karafin M, Romagnoli M, Fink DL, Howard T, Rau R, Milstone AM, et al. Fatal infection caused by Cupriavidus gilardii in a child with aplastic anemia. J Clin Microbiol. 2010;48(3):1005-7. DOI: 10.1128/JCM.01482-09

9. Stovall SH, Wisdom C, McKamie W, Ware W, Dedman H, Fiser RT. Nosocomial transmission of Cupriavidus pauculus during extracorporeal membrane oxygenation. ASAIO J. 2010;56(5):486-7. DOI: 10.1097/MAT.0b013e3181f0c80d

10. Langevin S, Vincelette J, Bekal S, Gaudreau C. First case of invasive human infection caused by Cupriavidus metallidurans. J Clin Microbiol. 2011;49(2):744-5. DOI: 10.1128/JCM.01947-10

11. Santiago AJ, Burgos-Garay ML, Kartforosh L, Mazher M, Donlan RM. Bacteriophage treatment of carbapenemase-producing Klebsiella pneumoniae in a multispecies biofilm: a potential biocontrol strategy for healthcare facilities. AIMS Microbiol. 2020;6(1):43-63. DOI: 10.3934/microbiol.2020003

12. Sohrabi A, Norouzfar ZS, Eslamifar A, Arashkia A, Azadmanesh K. Isolation of Cupriavidus metallidurans from razor blade during paraffin embedded tissue sectioning. Clin Lab. 2011;57(7-8):641

13. Coenye T, Spilker T, Reik R, Vandamme P, Lipuma JJ. Use of PCR analyses to define the distribution of Ralstonia species recovered from patients with cystic fibrosis. J Clin Microbiol. 2005;43(7):3463-6. DOI: 10.1128/JCM.43.7.3463-3466.2005

14. Spilker T, Coenye T, Vandamme P, LiPuma JJ. PCR-based assay for differentiation of Pseudomonas aeruginosa from other Pseudomonas species recovered from cystic fibrosis patients. J Clin Microbiol. 2004;42(5):2074-9. DOI: 10.1128/JCM.42.5.2074-2079.2004

15. Pasternak J. New methods of microbiological identification using MALDI-TOF. Einstein (Sao Paulo). 2012;10(1):118-9. DOI: 10.1590/s1679-45082012000100026

Downloads

Published

2024-11-01

How to Cite

Chapermann, F. J., & Sartorato, R. (2024). Nosocomial infection by Cupriavidus metallidurans. Infections in Evidence, 3, e20240945. https://doi.org/10.5935/2764-734X.e20240945

Issue

Vol. 3 (2024)

Section

Case Reports

License

Copyright (c) 2025 Infections in Evidence

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

The Copyright Transfer Agreement assumes that the authors are the legitimate holders of the copyright of the Case Report in question, without infringing any copyright, trademark or patent of others. In this way, they transfer all rights to this manuscript or any revision, version or translation of it to the Journal, including here the exclusivity of its eventual commercialization, provided that in accordance with ethical and moral precepts and relevant Brazilian legislation. All articles in the INFECTIONS IN EVIDENCE Journal are published under the terms of international license 4.0 of the Creative Commons Attribution, which allows users to freely read, download, share and adapt cultural and scientific productions, provided that due credit is given to the original authors and publication.
The Copyright Transfer Agreement also understands that the authors guarantee that the respective Case Report has never been published in another communication vehicle or scientific journal. Papers presented at meetings and/or scientific congresses may be published in the electronic journal INFECTIOUS DISEASES IN EVIDENCE - Case Reports, provided that they have not been published in whole or in part in their Proceedings or Annals.